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Pain and Inflammation? Try these caryophyllene cannabis strains.


Terpenes For Pain

Caryophyllene is a growing and sometimes abundant terpene present in cannabis products. The characteristic taste adds to the spiciness of black pepper and can be present in large quantities of garlic, hops and rosemary. It comes under the “generally accepted as healthy” range of the FDA, meaning that massive amounts can be safely ingested.

In the last decade, caryophyllene had attracted the attention of scientists when it was discovered to be one of the first non-cannabinoids to activate cannabinoid receptors correctly. Caryophyllene-rich cannabis plants may also have unique therapeutic benefits owing to the impact of this terpene on our endocannabinoid system.

Below, we should take a look at some of the possible benefits of caryophyllene and then explain what strains appear to have elevated amounts of this terpene and how to locate them.

The potential benefits of caryophyllene

CB2 receptors are present in inflammatory tissues in the body and are elevated throughout the brain due to disease or injury. Activity decreases inflammation, which lowers discomfort and eliminates the adverse impact of persistent inflammation on brain function and the likelihood of contracting brain disease.

CB1 and CB2 are the primary receptors of the endocannabinoid network of the body. CB1 receptors are most important in the nervous system. CB2 receptors that are activated by caryophyllene are more typical in certain areas, such as the immune system. (Elysse Feigenblatt) Work into caryophyllene is quite restricted. On the one side, it is tempting to generalize the medicinal advantages of caryophyllene based on the actions of certain substances that stimulate CB2 receptors. Overall, the stimulation of the CB2 receptor by certain substances may play a significant role in mitigating discomfort, avoiding epilepsy, and also decreasing plaque build-up in the arteries.

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But not all CB2 receptor activators have the same effect. Variations in the particular way that CB2 receptors are triggered by caryophyllene may contribute to differences in the severity of therapeutic results.


The evidence indicates that, in certain instances, caryophyllene can provide relief for the pain. In one study, scientists administered caryophyllene in mice and observed that they felt less discomfort than those handled with a control solution. In comparison, caryophyllene has improved the pain-reducing intensity of low-dose morphine. That may be one explanation that patients who take prescribed drugs with pain are always willing to reduce their dosage of narcotics as they continue using medical cannabis.

Inflammation and brain ageing

Several inflammatory disorders are impacting the digestive tract. Colitis is one such condition where inflammation of the intestines induces nausea, vomiting, intestinal cramping, and also raises the likelihood of cancer. Treatment of caryophyllene has tended to reduce inflammation in the colon in mice who have been experimentally diagnosed with colitis.

The activation of CB2 receptors by caryophyllene plays a role in its anti-pain function, but it also contributes to its ability to defend the body and brain from disease. For starters, brain inflammation plays a significant role in the development and progression of Alzheimer’s disease. In the mouse model of Alzheimer’s disease, caryophyllene triggered CB2 and PPAR-Δ receptors and decreased symptoms of Alzheimer’s disease, such as brain plaque formation. Such behaviour often guards against the cognitive impairment that characterizes this disease pattern.

Caryophyllene-dominant cannabis strains

Terpene - Caryophyllene
Terpene – Caryophyllene

Straits with elevated amounts of caryophyllene extend the weed continuum. It appears to be prevalent in terpenes such as Death Star, sativas such as Candyland, and hybrid strains such as GSC. In reality, several strains of the “Cookies” family have high levels of this terpene.

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Popular strains appear to express caryophyllene-dominant terpene profiles:

Finding strains high in caryophyllene

When choosing a strain that appears to be high in caryophyllene, bear in mind that specific goods might or may not be indicative of the actual composition of that strain, so most drug labels do not offer terpene profiles to customers. Conduct your homework and ask a professional dealer to suggest quality-reputed products.

While certain countries do not allow cannabis goods to have their terpene profiles calculated and marked, individual diligent and forward-thinking companies are taking the extra step of testing terpene profiles and presenting them to customers on the label. One of the most thoughtful things you can do as a customer; ask your pharmacies to display goods with branded terpene profiles and use your buying power to support companies who render this vital knowledge available.

It would be essential for customers to be able to shop for cannabis goods with checked terpene profiles, as terpenes such as caryophyllene, that provide different medicinal benefits to specific individuals. Yet we also have a lot to know about terpene hemp.

The future of caryophyllene research

One of the main concerns about the role that cannabis terpenes play in the medicinal effects of a plant is that they are released in adequate amounts to have an impact on the body. The current research trials have used isolated caryophyllene, sometimes at large doses. Are such levels significantly higher than what would be seen for a caryophyllene-rich cannabis strain? It’s not apparent at this stage.

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The future of caryophyllene (and all cannabis terpenes) work will include the analysis of terpene at levels associated with average human intake as well as in the presence of specific cannabinoids. This may be achieved by routinely changing the terpene rates while maintaining the amounts of other cannabis compounds stable. However, since caryophyllene can be safely applied to food, certain manufacturers might experiment with boosting caryophyllene rates at therapeutically appropriate doses.